Five years later… After a deadly journey across post-pandemic USA, Ellie and Joel settle down in Wyoming. Living in a thriving community gives them stability, despite the threat of the Infected and desperate survivors. When a violent event disrupts the peace, Ellie begins a relentless journey for justice. Hunting those responsible, she’s confronted by devastating physical and emotional repercussions of her actions.

At the age of nine, Lara survived a plane crash in the Himalayan mountains that resulted in the death of her mother. After miraculously surviving a ten-day solo trek from the crash site to Katmandu, she spent the rest of her childhood under the close tutelage of her Archaeologist father - the late Earl of Abbingdon, Richard Croft.

Set after the events of Uncharted 4: A Thief's End, Chloe Frazer (Claudia Black) enlists the aid of renowned mercenary Nadine Ross (Laura Bailey) in order to recover the Tusk of Ganesh, an Indian artifact Chloe's own father became obsessed with. They also endeavor to keep it out of the hands of Asav (Usman Ally), a ruthless war profiteer who endeavours to use the Tusk for his own personal gain.